Awesome bruh-goon appreciate the shit out of it Sixx
Fasho. 707 has good advice too, just do the settlement stuff first as you get a feel for the game. Once you get comfortable start doing missions and side missions (do lots of side missions, as mentioned before these are often the best).
I remember when I started playing New Vegas and I was confused as fuck at first, even the map was bizarre to me, but it was fun as hell learning how to interact with the universe. I'm sure this will be similar for you; while some stuff might be a little confusing at first it's not that kind of frustrating feeling you get like if you were to immediately jump into some massive MMO type game for the first time or some advanced warfare game where shit can be unbearably complicated. Fallout is fun and it's rewarding to explore and learn new things. A good mix of humor, more on the dark humor side, and serious game play.
Fallout games are one of the very few game series that I enjoy multiple play throughs. Usually I'm done with games when I beat the main mission unless there is cool multiplayer which gets inevitably boring after a while. Fallout is cool because you can build your character in different ways so it's entirely up to you if you want to be a charismatic smooth talker who can persuade people, or a beastly warrior who uses blunt objects to slaughter opponents, or a stealthy ninja who stays in the shadows and snipes enemies from afar, and there are multiple endings and choices to make so it's entirely up to you which way to go, making it rewarding to play again and again.