Yeah I've been quick saving out of habit from fo3/nv too, but it comes in handy if u unexpectedly die, like after a quick travel. That's annoying to have to go through a load screen then quick travel again promoting another quick travel.
I also had one mission glitch, where something was supposed to prompt but never did, reloaded last save and it worked fine.
Oh yeah btw, remember that video you posted where u can apparently go up walls by holding on too an item? Yesterday I was at a part where I had to get to the top of the building, I cleared out ever raider, looked forever on how to get up couldn't figure it out. So I'm thinking game glitched, damn it. So I'm trying to figure out something and decide, fuck it, gonna see if that Butcher video worked. Sure enough I get to the top of the building using this method, quickly do what I'm supposed to do. And then I see it. A fucking elevator. Lol completely missed it in the 30 minutes I wasted searching for a way up