I use throwing knife all the time, funny as fuck, and if you use it all the time youll get used to it, instead of reloading in a fight if he starts reloading i go in with the throwing knife ready, instant kill.
on another tip, I was going on a rampage the other night with my two .44 Magnum Revolvers in akimbo mode with fast reloading and was raping insanely! two shots kill a full healthed person so 1 shot of the 2 guns at the same time is an instant kill. Im getting used to that more than my primary weapon lol. recently unlocked tactical knife, im lovin it as well, you could slice people so much faster and easier, im really lovin this game