Some reading. All sources are 'Science' and 'Nature'.
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Origin of Large, Beneficial Mutations
Recent evolutionary studies "show how important large beneficial mutations are in the first stages of an adaptation," according to evolutionary biologist Doug Schemske of the University of Washington, Seattle. According to evolutionary theory, a new adaptation must be acquired fairly quickly, or else organisms will be poorly adapted to both the new and the old conditions and will not survive. Therefore, it seems logical that the first genetic changes must have large effects or else the changes will not be selected.
However, the observation that large beneficial mutations seem to occur (of course de novo creation is eliminated as a possibility) poses a problem, since these mutations are thought to be mostly rare and mostly disadvantageous when they do happen so "they contradict theory," according to Dr. H. Allen Orr, an evolutionary geneticist at University of Rochester in New York. "We're in a funny situation - we're about to have a wave of data crash down on us and no theory to hang it on." Dr. Orr has proposed a mathematical model to attempt to explain these data, although it is yet to be confirmed. It is remarkable how much data doesn't fit evolutionary theories, requiring the proposal of yet more new theories.
Morell, V. 1999. Size Matters: The Genes Behind Adaptation. Science 284: 2106.
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Although molecular biology has been used to hasten research in many fields of biology, it has failed to confirm the evolutionary mechanisms proposed by Darwinian theory. According to Dr. Paul Sharp, "Attempt to detect adaptive evolution at the molecular level have met with little success." Although the study described one of the few molecular successes of evolutionary theory, the trend has been that molecular biology contradicts much of evolutionary theory. (Sharp, P.M.. 1997. In search of molecular Darwinism. Nature 385: 111-112).
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Little or no evolution in ecological niches at the species level
S recent scientific study suggests that ecological niches evolve little or not at all at the time of a speciation event. The study shows ecological niche differences suddenly appear at the level of biological families. These results confirm the creation model seen in the Bible, which describes God's creative activities occurring at the level of "kinds" (which are similar to the biological classification of families). See page Naturalistic Biological Change and the Bible.
Peterson, A.T., J. Soberón, and V. Sánchez-Cordero. 1999. Conservatism of Ecological Niches in Evolutionary Time. Science 285: 1265-1267.
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Interdependent genes demonstrate limits to evolution
Irreducible complexity is something many evolutionists say does not exist in nature. The "reductionists" believe that there are no limits to an organism's variability and its ability to evolve. However, a new report demonstrates that when three characters are affected by a gene, the gene cannot change, but is constrained by the dependency of the other characteristics. Therefore, evolution is now falsifiable if organisms can be found that have broken this principle. In addition, this study demonstrates that the ability of organisms to evolve is limited. (Gunter Wagner. 1998. EVOLUTION: Complexity Matters Science 279:1158) and David Waxman, Joel R. Peck. 1998. Pleiotropy and the Preservation of Perfection Science 279: 1210.)