Seattle Seahawks (1-0) at San Francisco 49ers (1-0)
Weirdest stat line of Week 1: Frank Gore, 22 carries, 30 yards. Yikes. That's got to get better, and fast, and this won't be an easy week because Seattle's run defense is reborn, with 644 pounds of run-stoppers (Brandon Mebane and Colin Cole) there to shut him down. This might be Shaun Hill's game to win and, based on what I saw in Arizona last week, I think he can do it.
Prediction: San Francisco 49ers 23, Seattle Seahawks 16