De-Loused in the Comatorium is a concept album by the progressive rock band The Mars Volta. Based on a short story by lead singer Cedric Bixler Zavala, it is the hour-long tale of Cerpin Taxt, a man who tries to kill himself by overdosing on morphine. The attempt lands him in a week-long coma during which he experiences visions of humanity and his own psyche. Upon waking, he is dissatisfied with the real world and jumps to his death. The story of Cerpin Taxt is based on the death of El Paso, Texas artist (and Bixler Zavala's friend) Julio Venegas. Coincidentally, one month before the album was released, the band's sound manipulation artist, Jeremy Michael Ward, died of an apparent heroin overdose.
The music contained in De-Loused is distinguished by its enigmatic lyrics, Latin rhythms, odd time signatures, frequent tempo changes, and Omar Rodriguez-Lopez's frenetic guitar riffs, which are often harshly dissonant. The title of this album is taken from the lyrics of the song "Eunuch Provocateur" on the band's previous release, Tremulant.