I don't admit anything, these are facts, just as it is a fact that lifestyle is a huge factor
By stating the facts and not denying them, you are implying or directly stating the information is fact.
What I wanted to emphasize is that the lifestyle that can reduce your cancer risk is by no means the lifestyle of animals in the wild so it should not be called "natural", it is actually very artificial...
I would consider it neither "natural" nor "artificial" but BENEFICIAL or HEALTHY.
see, I am not speaking about genetic predisposition to cancer, I am speaking about why the species H.sapiens develops cancer when it could have been prevented to a much greater extent with some evolutionary adjustments...
But wouldn't evolutionary adjustments have a direct relation to genetic predisposition?
Some lower organisms like Planaria develop cancer very rarely as opposed to mammals The question is why is that and the answer is that the selective pressure simply has not been there...
And blacks are more prone to prostate cancer than asians, what exactly is your point? I understand worms are used in cancer research, but IMHO, you are comparing apples to oranges. It would appear that the more advanced somethign is, the more it will encounter problems.
Suppose you have a genetic variation that makes you less susceptible to cancer in late age
It provides no selective advantage to you because you have already reproduced and you're most likely dead by the time it will make you better off so it will not be stabilized in the population (you will not reproduce with a greater frequency than other individuals)
Now suppose you have a genetic variation that makes you more susceptible to cancer in late age.
Again, this provides no selective disadvantage to you because by the time you develop cancer, you have already reproduced and transmitted your "bad genes" to the next generation or you're most likely dead
I don't think you got it judging from your post
I DO get it. That is why I said, "I believe
that would depend on when you actually had kids. If you were 40+ when you had kids yes that would be applicable, but if you were in your 20's I don't see how that would work."
What you're saying is the selective advantage that will benefit you is basically useless to your body because it happened too late (when you were well in your years and on your death bed) and that it is too late to pass on the "good" genes because they were not passed on when they could have provided a benefit. If this is what you're saying, can you see why I said it depends on when you had kids?
You're generally right but in order to develop cancer you need to acumulate lots of mutations (at least 5 in most cases)
You need to mutate a master regulator of the cell cycle (Rb, INK4, ARF, etc), overactivate mitogenic signalling pathways (for example, oncogenic K-Ras, HER2, APC, or something like this), immortalize cells (overexpress hTERT) destabilize the genome (mutate some DNA repair proteins, or even better, p53), then you need a mesenchyme-to-epithelial transition in order to spawn metastasis, you need angiogenesis, etc.
These are lots of mutations and changes in the genome and it takes years and decades for all of them to occur.
Basically what you're saying are the mutations don't happen over night and because of this, it accumulates over time and surfaces when a person is well within there years. Quick question, when I was with my sister at Stanford medical a couple of years ago, we were told that the type of Lymphoma she had was generally found in white women 60+. However, my sister was a black woman in her late 40's, and they couldn't determine exactly why she had that form of cancer. Now, my question is because this is all in the genome, how much of her cancer can be attributed to genes or was it the result of life choices?
what is an "unnatural" mutation?????????????
Something that would be triggered from outside influences and would not have happened on its own.
WD said, "I just was wondering what exactly somatic lineage meant. The internet has not been helping."
Somatic cells are nonsex cells like the cells of your liver, your hair, your tonsils etc.