Get a RB first round, WR or another RB second, get a QB round 3 or 4, after that fill as needed.
You should be able to get a good defense and fill in your secondary WR's, get a decent TE and kicker in late rounds
my squad in the NFL.com Siccness league ended up pretty dope drafting like that
QB: Peyton Manning
RB: Jamaal Charles, Maurice Jones-Drew
WR: Torrey Smith, Calvin Johnson
TE: Kyle Rudolph
W/R: Ahmad Bradshaw
K: Justin Tucker
DEF: Broncos
BENCH:
QB: Colin Kaepernick
WR: Greg Jennings, Lance Moore, Hakeem Nicks
TE: Rob Gronkowski (bout to start when he gets back from injury)
DEF: Packers