I know I'm hella late to this thread, but I just picked the game back up after a year of not playing it.
There's so much shit to do it's kind of overwhelming lol. The looting drives me nuts because I wan to pick up everything and I can't.
I'll set out to finish a quest or storyline mission, and I'll end up scavenging a building for an hour or two. I'm like, "fuck, I didn't accomplish anything" lol.
It's a fun game though. I just leveled up to 19 and I'm about 53 hours in and am on my way to vault 112 (I think).