Coronavirus
- Thread starter RemyRoux
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MUST READ: Coronavirus-Are We Being Lied To Or Are The Experts Clueless?
Source: Coronavirus Research Mar 17, 2020 16 days ago
It getting terribly frustrating that as the team at Thailand Medical News peruses through hundreds of new research studies, some peer-reviewed and other not, it seems that WHO, the US CDC, NIH, government officials and health authorities as either not telling us something, are lying or are clueless.
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For instance, we are coming across lots of published studies that despite certain experts in the fields are claiming that the new SARS-CoV-2 coronavirus have not mutated or have mutated but not to the stage of not having any major effects, we have discovered at least 7 none peer reviewed studies and 3 peer-reviewed studies showing otherwise. Not only have mutations occurred but new strains of the virus have emerged with varying effects and properties.
As of yesterday, we came across the fact that there are at least 49 identified strains now but then again a few hours later upon publishing our article (https://www.thailandmedical.news/ne...-specific-preference-of-attacking-human-host-), we were informed by experts from Europe, US and China that there at least over a hundred plus strains as of now.
Pardon our stupidity and ignorance as the teams at Thailand Medical News only has a few GPs, a genomic specialist and an infectious disease specialist and a couple of medical researchers on our advisory team for the coronavirus beat, hence we are not as great as the experts out there, but reviewing the fact that major changes have taken place on the codons on the RNA genome of these strands, does it not have a bearing on the PCR nucleic test diagnostics? Does it not also have a bearing on drugs and vaccine developments?
The fact there are also more than one way for the virus to “attack’ or bind itself to human cells ie does it not have implications for treatment protocols and vaccine development and that in actual fact we might actually be losing the battle to even develop a proper treatment protocol in time and that is why some of the initial identified antivirals that were initially effective are no longer showing efficacy? (https://www.thailandmedical.news/ne...human-host-cells-making-it-a-real-super-virus)
Why are pharma companies and governments saying that there are vaccines on the way or are almost ready when all these new emerging data will change everything and delay the process more? Why is no one talking about the details of the coronavirus itself?
Also as rightfully as some of the Chinese researchers are saying, the residual or dormant viral loads in the body of “recovered” patients will have effects on the human body just like HPV has the ability to cause a variety of cancers or the herpes virus ability to cause neurodegenerative diseases etc. Why is it that only Thailand Medical News bringing these things up, why are no studies being conducted on these just yet considering the fact that Chinese researchers are warning that some of the numerous strains as a result of their mode of attack on human host cells indicates that low level infection of such strains can result in chronic diseases from cancer to tissue and organ damage. (Is this all fake news and misinformation? or something that is being covered up. Health authorities in China refused to comment when these questions were asked.)
The public has a right to know as it is our bodies that are being affected. It is not an issue to hide information so as to not cause panic or anxiety. Stop talking to us about washing our hands and social distancing etc, these are basic things that a common person with brains should already know.
Tell us the reality of the situation, tell us more about current research about the SARS-CoV-2 itself , tell us how it affects us, tell us in details about potential drug candidates etc, we do not want to be guinea pigs once we are infected.
We also hope that some real virologists and genomic experts out there who are not gagged will also tell the world what exactly is going on publicly.
Also on the issue about the transmission of the new coronavirus, initially the fact that it can be airborne was dismissed as being fake news and misinformation but now it’s an accepted fact with the current propaganda on social distancing etc. Besides the ‘aerosol mode’ etc, we at Thailand Medical News suggest that experts start looking into what is known as ‘super airborne mode’, where the virus is able to disperse in the air over a longer period and distance and can be further accelerated by wind currents covering a bigger area! (Fake news and misinformation again or a possibility!)
For more on the latest coronavirus research, keep logging on to Thailand Medical News
Source: Coronavirus Research Mar 17, 2020 16 days ago
It getting terribly frustrating that as the team at Thailand Medical News peruses through hundreds of new research studies, some peer-reviewed and other not, it seems that WHO, the US CDC, NIH, government officials and health authorities as either not telling us something, are lying or are clueless.
For instance, we are coming across lots of published studies that despite certain experts in the fields are claiming that the new SARS-CoV-2 coronavirus have not mutated or have mutated but not to the stage of not having any major effects, we have discovered at least 7 none peer reviewed studies and 3 peer-reviewed studies showing otherwise. Not only have mutations occurred but new strains of the virus have emerged with varying effects and properties.
As of yesterday, we came across the fact that there are at least 49 identified strains now but then again a few hours later upon publishing our article (https://www.thailandmedical.news/ne...-specific-preference-of-attacking-human-host-), we were informed by experts from Europe, US and China that there at least over a hundred plus strains as of now.
Pardon our stupidity and ignorance as the teams at Thailand Medical News only has a few GPs, a genomic specialist and an infectious disease specialist and a couple of medical researchers on our advisory team for the coronavirus beat, hence we are not as great as the experts out there, but reviewing the fact that major changes have taken place on the codons on the RNA genome of these strands, does it not have a bearing on the PCR nucleic test diagnostics? Does it not also have a bearing on drugs and vaccine developments?
The fact there are also more than one way for the virus to “attack’ or bind itself to human cells ie does it not have implications for treatment protocols and vaccine development and that in actual fact we might actually be losing the battle to even develop a proper treatment protocol in time and that is why some of the initial identified antivirals that were initially effective are no longer showing efficacy? (https://www.thailandmedical.news/ne...human-host-cells-making-it-a-real-super-virus)
Why are pharma companies and governments saying that there are vaccines on the way or are almost ready when all these new emerging data will change everything and delay the process more? Why is no one talking about the details of the coronavirus itself?
Also as rightfully as some of the Chinese researchers are saying, the residual or dormant viral loads in the body of “recovered” patients will have effects on the human body just like HPV has the ability to cause a variety of cancers or the herpes virus ability to cause neurodegenerative diseases etc. Why is it that only Thailand Medical News bringing these things up, why are no studies being conducted on these just yet considering the fact that Chinese researchers are warning that some of the numerous strains as a result of their mode of attack on human host cells indicates that low level infection of such strains can result in chronic diseases from cancer to tissue and organ damage. (Is this all fake news and misinformation? or something that is being covered up. Health authorities in China refused to comment when these questions were asked.)
The public has a right to know as it is our bodies that are being affected. It is not an issue to hide information so as to not cause panic or anxiety. Stop talking to us about washing our hands and social distancing etc, these are basic things that a common person with brains should already know.
Tell us the reality of the situation, tell us more about current research about the SARS-CoV-2 itself , tell us how it affects us, tell us in details about potential drug candidates etc, we do not want to be guinea pigs once we are infected.
We also hope that some real virologists and genomic experts out there who are not gagged will also tell the world what exactly is going on publicly.
Also on the issue about the transmission of the new coronavirus, initially the fact that it can be airborne was dismissed as being fake news and misinformation but now it’s an accepted fact with the current propaganda on social distancing etc. Besides the ‘aerosol mode’ etc, we at Thailand Medical News suggest that experts start looking into what is known as ‘super airborne mode’, where the virus is able to disperse in the air over a longer period and distance and can be further accelerated by wind currents covering a bigger area! (Fake news and misinformation again or a possibility!)
For more on the latest coronavirus research, keep logging on to Thailand Medical News
I cannot read that since they didnt use enough periods. Probably super smart article tho. I'm just not that smart.
Props:
RemyRoux and StillHustlin
https://www.medrxiv.org/content/10.1101/2020.03.10.20033944v2
Abstract
We found, in our 788 confirmed COVID-19 patients, the decreased rate of severe/critical type, increased liver/kidney damage and prolonged period of nuclear acid positivity during virus dissemination, when compared with Wuhan. To investigate the underlining mechanism, we isolated one strain of SARS- CoV-2 (ZJ01) in mild COVID-19 patient and found the existence of 35 specific gene mutation by gene alignment. Further phylogenetic analysis and RSCU heat map results suggested that ZJ01 may be a potential evolutionary branch of SARS-CoV-2. We classified 54 strains of viruses worldwide (C/T type) based on the base (C or T) at positions 8824 and 28247. ZJ01 were both T at these two sites, becoming the only TT type currently identified in the world. The prediction of Furin cleavage site (FCS) and the sequence alignment of virus family indicated that FCS may be an important site of coronavirus evolution. ZJ01 had mutations near FCS (F1-2), which caused changes in the structure and the electrostatic distribution of the S protein surface, further affecting the binding capacity of Furin. Single cell sequencing and ACE2-Furin co-expression results confirmed that Furin level was higher in the whole body, especially in glands, liver, kidney and colon while FCS may help SARS-CoV-2 infect these organs. The evolutionary pattern of SARS-CoV-2 towards FCS formation may result in its clinical symptom becoming closer to HKU-1 and OC43 (the source of FCS sequence-PRRA) caused influenza, further showing potential in differentiating into mild COVID-19 subtypes.
Competing Interest Statement
The authors have declared no competing interest.
Funding Statement
This research was supported by the National Key Program for Infectious Diseases of China (2017ZX10202202)，the National Natural Science Foundation of China (No. 81770574, 81870080), the National Key R&D Program of China, Stem Cell and Translation Research (2018YFA0109300) and Zhejiang Province Science Foundation for Distinguished Young Scholars (LR19H080001)
Author Declarations
All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript.
Yes
All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.
Yes
I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).
Yes
I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.
Yes
Abstract
We found, in our 788 confirmed COVID-19 patients, the decreased rate of severe/critical type, increased liver/kidney damage and prolonged period of nuclear acid positivity during virus dissemination, when compared with Wuhan. To investigate the underlining mechanism, we isolated one strain of SARS- CoV-2 (ZJ01) in mild COVID-19 patient and found the existence of 35 specific gene mutation by gene alignment. Further phylogenetic analysis and RSCU heat map results suggested that ZJ01 may be a potential evolutionary branch of SARS-CoV-2. We classified 54 strains of viruses worldwide (C/T type) based on the base (C or T) at positions 8824 and 28247. ZJ01 were both T at these two sites, becoming the only TT type currently identified in the world. The prediction of Furin cleavage site (FCS) and the sequence alignment of virus family indicated that FCS may be an important site of coronavirus evolution. ZJ01 had mutations near FCS (F1-2), which caused changes in the structure and the electrostatic distribution of the S protein surface, further affecting the binding capacity of Furin. Single cell sequencing and ACE2-Furin co-expression results confirmed that Furin level was higher in the whole body, especially in glands, liver, kidney and colon while FCS may help SARS-CoV-2 infect these organs. The evolutionary pattern of SARS-CoV-2 towards FCS formation may result in its clinical symptom becoming closer to HKU-1 and OC43 (the source of FCS sequence-PRRA) caused influenza, further showing potential in differentiating into mild COVID-19 subtypes.
Competing Interest Statement
The authors have declared no competing interest.
Funding Statement
This research was supported by the National Key Program for Infectious Diseases of China (2017ZX10202202)，the National Natural Science Foundation of China (No. 81770574, 81870080), the National Key R&D Program of China, Stem Cell and Translation Research (2018YFA0109300) and Zhejiang Province Science Foundation for Distinguished Young Scholars (LR19H080001)
Author Declarations
All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript.
Yes
All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.
Yes
I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).
Yes
I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.
Yes
The maker of Benson & Hedges and Lucky Strike cigarettes claims it has developed a coronavirus vaccine made from tobacco plants.
British American Tobacco (BAT) said it can manufacture up to three million doses a week starting in June if it gets support from the UK Government.
The unproven vaccine is currently being tested on animals. But BAT is calling on Whitehall to fast-track the vaccine through rigorous human trials which could otherwise take the best part of a year and make the June date impossible.
BAT said it had pivoted its vast resources - the company is worth £65.5billion - to fighting the pandemic.
The London-headquartered firm added that it would sell the tests to the Government 'at cost', meaning without making any profit.
Tobacco firms are currently barred from doing deals with governments under World Health Organisation rules, but BAT said it planned to contact the WHO.
British American Tobacco (BAT) said it can manufacture up to three million doses a week starting in June if it gets support from the UK Government.
The unproven vaccine is currently being tested on animals. But BAT is calling on Whitehall to fast-track the vaccine through rigorous human trials which could otherwise take the best part of a year and make the June date impossible.
BAT said it had pivoted its vast resources - the company is worth £65.5billion - to fighting the pandemic.
The London-headquartered firm added that it would sell the tests to the Government 'at cost', meaning without making any profit.
Tobacco firms are currently barred from doing deals with governments under World Health Organisation rules, but BAT said it planned to contact the WHO.
DigiVirus
Google is your master
https://www.reuters.com/article/us-health-coronavirus-google-idUSKBN21L0P7
Google releases location data to show if coronavirus lockdowns working in 131 countries
OAKLAND, California (Reuters) - Alphabet Inc’s Google on Thursday published reports for 131 countries showing whether visits to shops, parks and workplaces dropped in March, when many governments issued stay-at-home orders to rein in the spread of the novel coronavirus.
Google’s analysis of location data from billions of users’ phones is the largest public dataset available to help health authorities assess if people are abiding with shelter-in-place and similar orders issued across the world.
Its reports show charts that compare traffic from Feb. 16 to March 29 at subway, train and bus stations, grocery stores and other broad categories of places with a five-week period earlier this year.
In Italy, one of the countries hardest hit by the virus, visits to retail and recreation locations, including restaurants and movie theaters, plunged 94% while visits to workplaces slid 63%. Reflecting the severity of the crisis there, grocery and pharmacy visits in Italy dropped 85% and park visits were down by 90%.
In the United States, California, which was the first in the with a statewide lockdown, cut visits to retail and recreation locations by half. By contrast, Arkansas, one of the few states without a sweeping lockdown, has seen such visits fall 29%, the lowest for a U.S. state.
More at link
Google is your master
https://www.reuters.com/article/us-health-coronavirus-google-idUSKBN21L0P7
Google releases location data to show if coronavirus lockdowns working in 131 countries
OAKLAND, California (Reuters) - Alphabet Inc’s Google on Thursday published reports for 131 countries showing whether visits to shops, parks and workplaces dropped in March, when many governments issued stay-at-home orders to rein in the spread of the novel coronavirus.
Google’s analysis of location data from billions of users’ phones is the largest public dataset available to help health authorities assess if people are abiding with shelter-in-place and similar orders issued across the world.
Its reports show charts that compare traffic from Feb. 16 to March 29 at subway, train and bus stations, grocery stores and other broad categories of places with a five-week period earlier this year.
In Italy, one of the countries hardest hit by the virus, visits to retail and recreation locations, including restaurants and movie theaters, plunged 94% while visits to workplaces slid 63%. Reflecting the severity of the crisis there, grocery and pharmacy visits in Italy dropped 85% and park visits were down by 90%.
In the United States, California, which was the first in the with a statewide lockdown, cut visits to retail and recreation locations by half. By contrast, Arkansas, one of the few states without a sweeping lockdown, has seen such visits fall 29%, the lowest for a U.S. state.
More at link
RIP Ontario. We will replenish you with the Mexicans of the Midwest aka Norwegians
Props:
Mac Jesus and NotAllThere
They (Rockefeller Foundation) been planning this a long time
https://www.nommeraadio.ee/meedia/pdf/RRS/Rockefeller Foundation.pdf
https://www.nommeraadio.ee/meedia/pdf/RRS/Rockefeller Foundation.pdf
Hey the guy who can't even stop viruses on that sorry ass computer he wanted you to buy is going to find a legit vaccine for COVID-19.....he promises...it will totally be legit.....this time...version 2020
https://www.businessinsider.com.au/...ifferent-vaccines-to-fight-coronavirus-2020-4
https://www.businessinsider.com.au/...ifferent-vaccines-to-fight-coronavirus-2020-4
Props:
NotAllThere