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BUTCHER 206

BUTCHER 206

FREE BUTCHER206
#359,983
Aug 22, 2003
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#359,983
infinity said:
Citation needed
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Britney Spears, one-woman disaster zone, leaves hospital after two days | Americas | News | The Independent

The paper's front page celebrated the most outr of the rumours surrounding the singer with the line "Britney on horse drugs", a reference to claims that she has become addicted to Clenbuterol. This is ordinarily given to horses to aid breathing, but has been used and abused by people, such as dieters, seeking to speed up their metabolism.
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BUTCHER 206

BUTCHER 206

FREE BUTCHER206
#359,986
Aug 22, 2003
12,316
109,201
113
Seattle, WA
#359,986
Clenbuterol can induce fat burning via beta-2-adrenergic agonism; it is a highly selective B2 agonist. Via this mechanism, it induces fat burning by increases intra-cellular levels of cyclic AMP which has downstream effects on inducing protein kinase A (PKA) activity[25] which then acts on hormone sensitive lipase (HSL) and perilipin to mediate lipolysis;[26] insulin is a negative mediator of this pathway.[27] PKA may also induce CREB phosphorylation, which is then able to induce JHDM2a (a histone demethylase) promoter activity[11] and may have downstream influences on PPARα and UCP1, two proteins involved in fatty acid oxidation and uncoupling (respectively).

Clenbuterol seems to highly affect the genetic signalling of adipocytes, with one porcine study noted 82 different mRNA expression rates following adipocyte incubation with clenbuterol[20]

Clenbuterol is a potent β2-adrenergic receptor agonist and activates the downstream consequences of β2-receptors, which is mostly fat burning with some muscle protein synthesis. This is the receptor class that adrenaline acts upon





Hell yeah lol who wouldn't want to walk around amped up like they're constantly in an adrenaline rush, that sounds amazing
 
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