November 20, 2010 at The Palace of Auburn Hills in the Detroit suburb of Auburn Hills, Michigan
Main card
*Light Heavyweight bout: Lyoto Machida vs. Quinton Jackson
*Welterweight bout: Matt Hughes vs. B.J. Penn
*Middleweight bout: Gerald Harris vs. Maiquel Falcão
*Light Heavyweight bout: Phil Davis vs. Tim Boetsch
*Lightweight bout: George Sotiropoulos vs. Joe Lauzon
Spike TV card
*Welterweight bout: Matt Brown vs. Brian Foster
*Middleweight bout: Aaron Simpson vs. Mark Muñoz
Preliminary card
*Welterweight bout: Karo Parisyan vs. Dennis Hallman
*Lightweight bout: Darren Elkins vs. Edson Barboza
*Lightweight bout: Tyson Griffin vs. Nik Lentz
*Lightweight bout: Paul Kelly vs. T.J. O'Brien