http://www.museumofhoaxes.com/hoax/Top/experiments/P0
#1: Elephants on Acid
imageWhat happens if you give an elephant LSD? On Friday August 3, 1962, a group of Oklahoma City researchers decided to find out.
Warren Thomas, Director of the City Zoo, fired a cartridge-syringe containing 297 milligrams of LSD into Tusko the Elephant's rump. With Thomas were two scientific colleagues from the University of Oklahoma School of Medicine, Louis Jolyon West and Chester M. Pierce.
297 milligrams is a lot of LSD — about 3000 times the level of a typical human dose. In fact, it remains the largest dose of LSD ever given to a living creature. The researchers figured that, if they were going to give an elephant LSD, they better not give him too little.
Thomas, West, and Pierce later explained that the experiment was designed to find out if LSD would induce musth in an elephant — musth being a kind of temporary madness male elephants sometimes experience during which they become highly aggressive and secrete a sticky fluid from their temporal glands. But one suspects a small element of ghoulish curiosity might also have been involved.
Whatever the reason for the experiment, it almost immediately went awry. Tusko reacted to the shot as if a bee had stung him. He trumpeted around his pen for a few minutes, and then keeled over on his side. Horrified, the researchers tried to revive him, but about an hour later he was dead. The three scientists sheepishly concluded that, "It appears that the elephant is highly sensitive to the effects of LSD."
In the years that followed controversy lingered over whether it was the LSD that killed Tusko, or the drugs used to revive him. So twenty years later, Ronald Siegel of UCLA decided to settle the debate by giving two elephants a dose similar to what Tusko received. Reportedly he had to sign an agreement promising to replace the animals in the event of their deaths.
Instead of injecting the elephants with LSD, Siegel mixed the drug into their water, and when it was administered in this way, the elephants not only survived but didn't seem too upset at all. They acted sluggish, rocked back and forth, and made some strange vocalizations such as chirping and squeaking, but within a few hours they were back to normal. However, Siegel noted that the dosage Tusko received may have exceeded some threshold of toxicity, so he couldn't rule out that LSD was the cause of his death. The controversy continues.
Comments (16)
#2: Obedience
imageImagine that you've volunteered for an experiment, but when you show up at the lab you discover the researcher wants you to murder an innocent person. You protest, but the researcher firmly states, "The experiment requires that you do it." Would you acquiesce and kill the person?
When asked what they would do in such a situation, almost everyone replies that of course they would refuse to commit murder. But Stanley Milgram's famous obedience experiment, conducted at Yale University in the early 1960s, revealed that this optimistic belief is wrong. If the request is presented in the right way, almost all of us quite obediently become killers.
Milgram told subjects they were participating in an experiment to determine the effect of punishment on learning. One volunteer (who was, in reality, an actor in cahoots with Milgram) would attempt to memorize a series of word pairs. The other volunteer (the real subject) would read out the word pairs and give the learner an electric shock every time he got an answer wrong. The shocks would increase in intensity by fifteen volts with each wrong answer.
The experiment began. The learner started getting some wrong answers, and pretty soon the shocks had reached 120 volts. At this point the learner started crying out, "Hey, this really hurts." At 150 volts the learner screamed in pain and demanded to be let out. Confused, the volunteers turned around and asked the researcher what they should do. He always calmly replied, "The experiment requires that you continue."
Milgram had no interest in the effect of punishment on learning. What he really wanted to see was how long people would keep pressing the shock button before they refused to participate any further. Would they remain obedient to the authority of the researcher up to the point of killing someone?
To Milgram's surprise, even though volunteers could plainly hear the agonized cries of the learner echoing through the walls of the lab from the neighboring room, two-thirds of them continued to press the shock button all the way up to the end of scale, 450 volts, by which time the learner had fallen into an eerie silence, apparently dead. Milgram's subjects sweated and shook, and some laughed hysterically, but they kept pressing the button. Even more disturbingly, when volunteers could neither see nor hear feedback from the learner, compliance with the order to give ever greater shocks was almost 100%.
Milgram later commented, "I would say, on the basis of having observed a thousand people in the experiment and having my own intuition shaped and informed by these experiments, that if a system of death camps were set up in the United States of the sort we had seen in Nazi Germany, one would be able to find sufficient personnel for those camps in any medium-sized American town."
#3: Demikhov’s Two-Headed Dogs
imageIn 1954 Vladimir Demikhov shocked the world by unveiling a surgically created monstrosity: A two-headed dog. He created the creature in a lab on the outskirts of Moscow by grafting the head, shoulders, and front legs of a puppy onto the neck of a mature German shepherd.
Demikhov paraded the dog before reporters from around the world. Journalists gasped as both heads simultaneously lapped at bowls of milk, and then cringed as the milk from the puppy's head dribbled out the unconnected stump of its esophageal tube. The Soviet Union proudly boasted that the dog was proof of their nation's medical preeminence.
Over the course of the next fifteen years, Demikhov created a total of twenty of his two-headed dogs. None of them lived very long, as they inevitably succumbed to problems of tissue rejection. The record was a month.
Demikhov explained that the dogs were part of a continuing series of experiments in surgical techniques, with his ultimate goal being to learn how to perform a human heart and lung transplant. Another surgeon beat him to this goal — Dr. Christian Baarnard in 1967 — but Demikhov is widely credited with paving the way for it.
In 1954 James Olds and Peter Milner of McGill University discovered that the septal region is the feel-good center of the brain. Electrical stimulation of it produces sensations of intense pleasure and sexual arousal. They demonstrated their discovery by inserting wires into a rat's brain and then showing that when the rat figured out it could self-stimulate itself by pressing a lever, it would maniacally bang on that lever up to two-thousand times an hour. (The image at the very top of this page, third from the right, shows one of Olds and Milner's rats banging on its lever.)
In 1970, Robert Heath of Tulane University dreamed up a far more novel application of Olds and Milner's discovery. Heath decided to test whether repeated stimulation of the septal region could transform a homosexual man into a heterosexual.
Heath referred to his homosexual subject as patient B-19. He inserted Teflon-insulated electrodes into the septal region of B-19's brain and then gave B-19 carefully controlled amounts of stimulation in experimental sessions. Soon the young man was reporting increased stirrings of sexual motivation. Heath then rigged up a device to allow B-19 to self-stimulate himself. It was like letting a chocoholic loose in a candy shop. B-19 quickly became obsessed with the pleasure button. In one three-hour session he pressed it 1500 times until, as Heath noted, "he was experiencing an almost overwhelming euphoria and elation and had to be disconnected."
By this stage of the experiment B-19's libido was so jacked up that Heath decided to proceed with the final stage in which B-19 would be introduced to a sexually-willing female partner. With permission from the state attorney general, Heath arranged for a twenty-one-year-old female prostitute to visit the lab, and he placed her in a room with B-19. For an hour B-19 did nothing, but then the prostitute took the initiative and a successful sexual encounter between the two occurred. Heath considered this a positive result.
Little is known of B-19's later fate. Heath reported that the young man drifted back into a life of homosexual prostitution, but that he also had an affair with a married woman. Heath optimistically decided that this showed the treatment was at least partially successful. However, Heath never did try to convert any more homosexuals.
#5: The Isolated Head of a Dog
imageWhat could be more horrific than creating a two-headed dog? What about keeping the severed head of a dog alive apart from its body!
Ever since the carnage of the French Revolution, when the guillotine sent thousands of severed heads tumbling into baskets, scientists had wondered whether it would be possible to keep a head alive apart from its body, but it wasn't until the late 1920s that someone managed to pull off this feat.
Soviet physician Sergei Brukhonenko developed a primitive heart-lung machine he called an "autojector," and with this device he succeeded in keeping the severed head of a dog alive. He displayed one of his living dog heads in 1928 before an international audience of scientists at the Third Congress of Physiologists of the USSR. To prove that the head lying on the table really was alive, he showed that it reacted to stimuli. Brukhonenko banged a hammer on the table, and the head flinched. He shone light in its eyes, and the eyes blinked. He even fed the head a piece of cheese, which promptly popped out the esophageal tube on the other end.
Brukhonenko's severed dog head became the talk of Europe and inspired the playwright George Bernard Shaw to muse, "I am even tempted to have my own head cut off so that I can continue to dictate plays and books without being bothered by illness, without having to dress and undress, without having to eat, without having anything else to do other than to produce masterpieces of dramatic art and literature."
#1: Elephants on Acid
imageWhat happens if you give an elephant LSD? On Friday August 3, 1962, a group of Oklahoma City researchers decided to find out.
Warren Thomas, Director of the City Zoo, fired a cartridge-syringe containing 297 milligrams of LSD into Tusko the Elephant's rump. With Thomas were two scientific colleagues from the University of Oklahoma School of Medicine, Louis Jolyon West and Chester M. Pierce.
297 milligrams is a lot of LSD — about 3000 times the level of a typical human dose. In fact, it remains the largest dose of LSD ever given to a living creature. The researchers figured that, if they were going to give an elephant LSD, they better not give him too little.
Thomas, West, and Pierce later explained that the experiment was designed to find out if LSD would induce musth in an elephant — musth being a kind of temporary madness male elephants sometimes experience during which they become highly aggressive and secrete a sticky fluid from their temporal glands. But one suspects a small element of ghoulish curiosity might also have been involved.
Whatever the reason for the experiment, it almost immediately went awry. Tusko reacted to the shot as if a bee had stung him. He trumpeted around his pen for a few minutes, and then keeled over on his side. Horrified, the researchers tried to revive him, but about an hour later he was dead. The three scientists sheepishly concluded that, "It appears that the elephant is highly sensitive to the effects of LSD."
In the years that followed controversy lingered over whether it was the LSD that killed Tusko, or the drugs used to revive him. So twenty years later, Ronald Siegel of UCLA decided to settle the debate by giving two elephants a dose similar to what Tusko received. Reportedly he had to sign an agreement promising to replace the animals in the event of their deaths.
Instead of injecting the elephants with LSD, Siegel mixed the drug into their water, and when it was administered in this way, the elephants not only survived but didn't seem too upset at all. They acted sluggish, rocked back and forth, and made some strange vocalizations such as chirping and squeaking, but within a few hours they were back to normal. However, Siegel noted that the dosage Tusko received may have exceeded some threshold of toxicity, so he couldn't rule out that LSD was the cause of his death. The controversy continues.
Comments (16)
#2: Obedience
imageImagine that you've volunteered for an experiment, but when you show up at the lab you discover the researcher wants you to murder an innocent person. You protest, but the researcher firmly states, "The experiment requires that you do it." Would you acquiesce and kill the person?
When asked what they would do in such a situation, almost everyone replies that of course they would refuse to commit murder. But Stanley Milgram's famous obedience experiment, conducted at Yale University in the early 1960s, revealed that this optimistic belief is wrong. If the request is presented in the right way, almost all of us quite obediently become killers.
Milgram told subjects they were participating in an experiment to determine the effect of punishment on learning. One volunteer (who was, in reality, an actor in cahoots with Milgram) would attempt to memorize a series of word pairs. The other volunteer (the real subject) would read out the word pairs and give the learner an electric shock every time he got an answer wrong. The shocks would increase in intensity by fifteen volts with each wrong answer.
The experiment began. The learner started getting some wrong answers, and pretty soon the shocks had reached 120 volts. At this point the learner started crying out, "Hey, this really hurts." At 150 volts the learner screamed in pain and demanded to be let out. Confused, the volunteers turned around and asked the researcher what they should do. He always calmly replied, "The experiment requires that you continue."
Milgram had no interest in the effect of punishment on learning. What he really wanted to see was how long people would keep pressing the shock button before they refused to participate any further. Would they remain obedient to the authority of the researcher up to the point of killing someone?
To Milgram's surprise, even though volunteers could plainly hear the agonized cries of the learner echoing through the walls of the lab from the neighboring room, two-thirds of them continued to press the shock button all the way up to the end of scale, 450 volts, by which time the learner had fallen into an eerie silence, apparently dead. Milgram's subjects sweated and shook, and some laughed hysterically, but they kept pressing the button. Even more disturbingly, when volunteers could neither see nor hear feedback from the learner, compliance with the order to give ever greater shocks was almost 100%.
Milgram later commented, "I would say, on the basis of having observed a thousand people in the experiment and having my own intuition shaped and informed by these experiments, that if a system of death camps were set up in the United States of the sort we had seen in Nazi Germany, one would be able to find sufficient personnel for those camps in any medium-sized American town."
#3: Demikhov’s Two-Headed Dogs
imageIn 1954 Vladimir Demikhov shocked the world by unveiling a surgically created monstrosity: A two-headed dog. He created the creature in a lab on the outskirts of Moscow by grafting the head, shoulders, and front legs of a puppy onto the neck of a mature German shepherd.
Demikhov paraded the dog before reporters from around the world. Journalists gasped as both heads simultaneously lapped at bowls of milk, and then cringed as the milk from the puppy's head dribbled out the unconnected stump of its esophageal tube. The Soviet Union proudly boasted that the dog was proof of their nation's medical preeminence.
Over the course of the next fifteen years, Demikhov created a total of twenty of his two-headed dogs. None of them lived very long, as they inevitably succumbed to problems of tissue rejection. The record was a month.
Demikhov explained that the dogs were part of a continuing series of experiments in surgical techniques, with his ultimate goal being to learn how to perform a human heart and lung transplant. Another surgeon beat him to this goal — Dr. Christian Baarnard in 1967 — but Demikhov is widely credited with paving the way for it.
In 1954 James Olds and Peter Milner of McGill University discovered that the septal region is the feel-good center of the brain. Electrical stimulation of it produces sensations of intense pleasure and sexual arousal. They demonstrated their discovery by inserting wires into a rat's brain and then showing that when the rat figured out it could self-stimulate itself by pressing a lever, it would maniacally bang on that lever up to two-thousand times an hour. (The image at the very top of this page, third from the right, shows one of Olds and Milner's rats banging on its lever.)
In 1970, Robert Heath of Tulane University dreamed up a far more novel application of Olds and Milner's discovery. Heath decided to test whether repeated stimulation of the septal region could transform a homosexual man into a heterosexual.
Heath referred to his homosexual subject as patient B-19. He inserted Teflon-insulated electrodes into the septal region of B-19's brain and then gave B-19 carefully controlled amounts of stimulation in experimental sessions. Soon the young man was reporting increased stirrings of sexual motivation. Heath then rigged up a device to allow B-19 to self-stimulate himself. It was like letting a chocoholic loose in a candy shop. B-19 quickly became obsessed with the pleasure button. In one three-hour session he pressed it 1500 times until, as Heath noted, "he was experiencing an almost overwhelming euphoria and elation and had to be disconnected."
By this stage of the experiment B-19's libido was so jacked up that Heath decided to proceed with the final stage in which B-19 would be introduced to a sexually-willing female partner. With permission from the state attorney general, Heath arranged for a twenty-one-year-old female prostitute to visit the lab, and he placed her in a room with B-19. For an hour B-19 did nothing, but then the prostitute took the initiative and a successful sexual encounter between the two occurred. Heath considered this a positive result.
Little is known of B-19's later fate. Heath reported that the young man drifted back into a life of homosexual prostitution, but that he also had an affair with a married woman. Heath optimistically decided that this showed the treatment was at least partially successful. However, Heath never did try to convert any more homosexuals.
#5: The Isolated Head of a Dog
imageWhat could be more horrific than creating a two-headed dog? What about keeping the severed head of a dog alive apart from its body!
Ever since the carnage of the French Revolution, when the guillotine sent thousands of severed heads tumbling into baskets, scientists had wondered whether it would be possible to keep a head alive apart from its body, but it wasn't until the late 1920s that someone managed to pull off this feat.
Soviet physician Sergei Brukhonenko developed a primitive heart-lung machine he called an "autojector," and with this device he succeeded in keeping the severed head of a dog alive. He displayed one of his living dog heads in 1928 before an international audience of scientists at the Third Congress of Physiologists of the USSR. To prove that the head lying on the table really was alive, he showed that it reacted to stimuli. Brukhonenko banged a hammer on the table, and the head flinched. He shone light in its eyes, and the eyes blinked. He even fed the head a piece of cheese, which promptly popped out the esophageal tube on the other end.
Brukhonenko's severed dog head became the talk of Europe and inspired the playwright George Bernard Shaw to muse, "I am even tempted to have my own head cut off so that I can continue to dictate plays and books without being bothered by illness, without having to dress and undress, without having to eat, without having anything else to do other than to produce masterpieces of dramatic art and literature."