Any starting QB's left undrafted?
Trade Manning away for some more quality at RB and WR - you're lacking top tier players in those areas. I bet someone will jump and give up something good if you're willing to part with Manning.
If you're not willing to make that big of a leap your first year you better hit the waivers HARD and WISE.
Losing your "starting" QB/TE/ and a WR all in the same week is going to suck when the Colts go on a bye. Might want to chalk that up to an L now. Being mindful of bye weeks can help.