2 off the top of my head.
Mr. Show with Bob and David-one of the greatest and most overlooked sketch comedies of all time. It may be a little weird, and hard to get used to at first, but the stuff they came up with is just so genious, the way they just made fun of other things. There was only 4 seasons, and it was on HBO, and hbo cut it when it was at its peak. All of the people associated with this show, (one of them is the creator and voice of Spongebob) are just so smart and know how to make normal situations funny.
Arrested Developments-one of the freshest, most crisps comedies/sitcoms to come out in a long time. All of the characters are funny, its got a great cast, (jason bateman, jeffrey tambor, portia de rossi, etc) and the script is hilarious. David cross, formerly of mr. show also had a great character.
The Wayans Brothers show i thought was funny, and i know it wasnt the greatest show, but i really liked it...but it was on teh WB so u knew it wastn gonna last long.
i also like the Steve Harvey show, but that kinda went in the same direction as the wayans brothers show.